- Biofreeze Pain relief is deep penetrating and long lasting for arthritis, sore muscles, joint and pack pain. Gel can be applied for instant relief body parts such as the foot, ankle, knee, hand, wrist, elbow, hip, back, neck and shoulders. Biofreeze On-the-Go Singles fit perfectly in pockets, purses, gym bags, or travel bags so they are ideal for pain relief at home, at work, or anywhere life takes you.